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1

The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities?

Stahl, Stephen M., Porreca, Frank, Taylor, Charles P., Cheung, Raymond, Thorpe, Andrew J., Clair, Andrew

Journal:

Trends in Pharmacological Sciences

Year:

2013

Language:

english

File:

PDF, 1.30 MB

english, 2013

2

Positive emotions and brain reward circuits in chronic pain

Navratilova, Edita, Morimura, Kozo, Xie, Jennifer Y., Atcherley, Christopher W., Ossipov, Michael H., Porreca, Frank

Journal:

The Journal of Comparative Neurology

Year:

2016

Language:

english

File:

PDF, 930 KB

english, 2016

3

Pathophysiology, prevention, and treatment of medication overuse headache

Diener, Hans-Christoph, Dodick, David, Evers, Stefan, Holle, Dagny, Jensen, Rigmor Hoejland, Lipton, Richard B, Porreca, Frank, Silberstein, Stephen, Schwedt, Todd

Journal:

The Lancet Neurology

Year:

2019

Language:

english

File:

PDF, 789 KB

english, 2019

4

Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial

Martin, Laurent, Porreca, Frank, Mata, Elizabeth I, Salloum, Michelle, Goel, Vasudha, Gunnala, Pooja, Killgore, Wiliam D S, Jain, Sejal, Jones-MacFarland, Felesia N, Khanna, Rajesh, Patwardhan, Amol,

Journal:

Year:

2020

File:

PDF, 1.07 MB

2020

5

Brain Circuits Encoding Reward from Pain Relief

Navratilova, Edita, Atcherley, Christopher W., Porreca, Frank

Journal:

Trends in Neurosciences

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

6

Reward, motivation, and emotion of pain and its relief

Porreca, Frank, Navratilova, Edita

Journal:

Year:

2017

Language:

english

File:

PDF, 195 KB

english, 2017

7

Pathophysiology, prevention, and treatment of medication overuse headache

Diener, Hans-Christoph, Dodick, David, Evers, Stefan, Holle, Dagny, Jensen, Rigmor Hoejland, Lipton, Richard B, Porreca, Frank, Silberstein, Stephen, Schwedt, Todd

Journal:

The Lancet Neurology

Year:

2019

File:

PDF, 789 KB

2019

8

Triptan-induced latent sensitization: A possible basis for medication overuse headache

Milena De Felice, Michael H. Ossipov, Ruizhong Wang, Josephine Lai, Juliana Chichorro, Ian Meng, David W. Dodick, Todd W. Vanderah, Gregory Dussor, Frank Porreca

Journal:

Annals of Neurology

Year:

2010

Language:

english

File:

PDF, 2.77 MB

english, 2010

9

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity

Ravil R. Petrov, Ruben S. Vardanyan, Yeon S. Lee, Shou-wu Ma, Peg Davis, Lucinda J. Begay, Josephine Y. Lai, Frank Porreca, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

10

The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety

Takashi Yamamoto, Padma Nair, Shou-wu Ma, Peg Davis, Henry I. Yamamura, Todd W. Vanderah, Frank Porreca, Josephine Lai, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 298 KB

english, 2009

11

Update on Medication-overuse Headache

Milena De Felice, Michael H. Ossipov, Frank Porreca

Journal:

Current Pain and Headache Reports

Year:

2011

Language:

english

File:

PDF, 123 KB

english, 2011

12

cis -4-Amino- l -proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2

Mollica, Adriano, Pinnen, Francesco, Stefanucci, Azzurra, Mannina, Luisa, Sobolev, Anatoly P., Lucente, Gino, Davis, Peg, Lai, Josephine, Ma, Shou-Wu, Porreca, Frank, Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 524 KB

english, 2012

13

VOLTAGE-GATED SODIUM CHANNELS AND HYPERALGESIA

Porreca, Frank, Hunter, John C., Gold, Michael S., Lai, Josephine

Journal:

Annual Review of Pharmacology

Year:

2004

Language:

english

File:

PDF, 346 KB

english, 2004

14

Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

Josephine Lai, Shou-wu Ma, Frank Porreca, Robert B. Raffa

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 341 KB

english, 1996

15

Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors

Tinna M Laughlin, Todd W Vanderah, Jason Lashbrook, Mike L Nichols, Mike Ossipov, Frank Porreca, George L Wilcox

Journal:

Year:

1997

Language:

english

File:

PDF, 324 KB

english, 1997

16

Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy

Xie, Jennifer Y., Qu, Chaoling, Patwardhan, Amol, Ossipov, Michael H., Navratilova, Edita, Becerra, Lino, Borsook, David, Porreca, Frank

Journal:

Year:

2014

Language:

english

File:

PDF, 893 KB

english, 2014

17

Reward and motivation in pain and pain relief

Navratilova, Edita, Porreca, Frank

Journal:

Nature Neuroscience

Year:

2014

Language:

english

File:

PDF, 582 KB

english, 2014

18

Structure−Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors

Agnes, Richard S., Lee, Yeon Sun, Davis, Peg, Ma, Shou-wu, Badghisi, Hamid, Porreca, Frank, Lai, Josephine, Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 89 KB

english, 2006

19

Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache

De Felice, Milena, Ossipov, Michael H, Porreca, Frank

Journal:

Current Opinion in Neurology

Year:

2011

Language:

english

File:

PDF, 147 KB

english, 2011

20

The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia

Flores, Andrew J., Bartlett, Mitchell J., Root, Brandon K., Parent, Kate L., Heien, Michael L., Porreca, Frank, Polt, Robin, Sherman, Scott J., Falk, Torsten

Journal:

Neuropharmacology

Year:

2018

Language:

english

File:

PDF, 2.24 MB

english, 2018

21

Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system

Jassar, Hassan, Nascimento, Thiago D., Kaciroti, Niko, DosSantos, Marcos F., Danciu, Theodora, Koeppe, Robert A., Smith, Yolanda R., Bigal, Marcelo E., Porreca, Frank, Casey, Kenneth L., Zubieta, Jon-

Journal:

NeuroImage: Clinical

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

22

Amygdala, neuropeptides, and chronic pain-related affective behaviors

Neugebauer, Volker, Mazzitelli, Mariacristina, Cragg, Bryce, Ji, Guangchen, Navratilova, Edita, Porreca, Frank

Journal:

Neuropharmacology

Year:

2020

Language:

english

File:

PDF, 1.53 MB

english, 2020

23

Conformational restriction of Tyr and Phe side chains in opioid peptides: Information about preferred and bioactive side-chain topology

Dirk Tourwé, Kris Verschueren, Anne Frycia, Peg Davis, Frank Porreca, Victor J. Hruby, Geza Toth, Hendrika Jaspers, Patricia Verheyden, Georges Van Binst

Journal:

Year:

1996

Language:

english

File:

PDF, 789 KB

english, 1996

24

Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat μ opioid receptor

Yi-Feng Lu, Heng Xu, Lee-Yuan Liu-Chen, Chongguang Chen, John S. Partilla, George A. Brine, F. Ivy Carroll, Kenner C. Rice, Josephine Lai, Frank Porreca, Wolfgang Sadee, Richard B. Rothman

Journal:

Year:

1998

Language:

english

File:

PDF, 171 KB

english, 1998

25

α-Azido acids for direct use in solid-phase peptide synthesis

Christian W. Tornøe, Peg Davis, Frank Porreca, Morten Meldal

Journal:

Journal of Peptide Science

Year:

2000

Language:

english

File:

PDF, 136 KB

english, 2000

26

Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues

Xuyuan Gu, Jinfa Ying, Byoung Min, James P. Cain, Peg Davis, Patrick Willey, Edita Navratilova, Henry I. Yamamura, Frank Porreca, Victor J. Hruby

Journal:

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

27

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

Michael H. Ossipov, Josephine Lai, Tamara King, Todd W. Vanderah, Frank Porreca

Journal:

Year:

2005

Language:

english

File:

PDF, 74 KB

english, 2005

28

Synthesis, Opioid Receptor Binding, and Functional Activity of 5′-Substituted 17-Cyclopropylmethylpyrido[2′,3′:6,7]morphinans.

Subramaniam Ananthan, Hollis S. III Kezar, Surendra K. Saini, Naveen K. Khare, Peg Davis, Christina M. Dersch, Frank Porreca, Richard B. Rothman

Journal:

Year:

2003

File:

PDF, 75 KB

2003

29

Stereoselective Synthesis of Individual Isomers of Leu-enkephalin Analogues Containing Substituted β-Turn Bicyclic Dipeptide Mimetics.

Chiyi Xiong, Junyi Zhang, Peg Davis, Wei Wang, Jinfa Ying, Frank Porreca, Victor J. Hruby

Journal:

Year:

2003

File:

PDF, 140 KB

2003

30

Modulation of neurotrophic growth factors as a therapeutic strategy for neuropathic pain

Dinah Y.W. Sah, Frank Porreca, Michael H. Ossipov

Journal:

Drug Development Research

Year:

2006

Language:

english

File:

PDF, 174 KB

english, 2006

31

Characterization of the unusual antinociceptive profile of tramadol in mice

Antonia Mattia, Todd Vanderah, Robert B. Raffa, Jeffry L. Vaught, Ronald J. Tallarida, Frank Porreca

Journal:

Drug Development Research

Year:

1993

Language:

english

File:

PDF, 649 KB

english, 1993

32

Antinociceptive and nociceptive actions of opioids

Michael H. Ossipov, Josephine Lai, Tamara King, Todd W. Vanderah, T. Philip Malan Jr., Victor J. Hruby, Frank Porreca

Journal:

Developmental Neurobiology

Year:

2004

Language:

english

File:

PDF, 167 KB

english, 2004

33

Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at μ and δ opioid receptors

Yeon Sun Lee, Joel Nyberg, Sharif Moye, Richard S. Agnes, Peg Davis, Shou-wu Ma, Josephine Lai, Frank Porreca, Ruben Vardanyan, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 334 KB

english, 2007

34

Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502)

Severo Salvadori, Stella Fiorini, Claudio Trapella, Frank Porreca, Peg Davis, Yusuke Sasaki, Akihiro Ambo, Ewa D. Marczak, Lawrence H. Lazarus, Gianfranco Balboni

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

35

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain

Ruben Vardanyan, Gokhale Vijay, Gary S. Nichol, Lu Liu, Isuru Kumarasinghe, Peg Davis, Todd Vanderah, Frank Porreca, Josephine Lai, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 397 KB

english, 2009

36

Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers

Adriano Mollica, Peg Davis, Shou-Wu Ma, Josephine Lai, Frank Porreca, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

37

Synthesis and biological activity of the first cyclic biphalin analogues

Adriano Mollica, Peg Davis, Shou-Wu Ma, Frank Porreca, Josephine Lai, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

38

Synthesis and evaluation of new endomorphin analogues modified at the Pro2 residue

Domenica Torino, Adriano Mollica, Francesco Pinnen, Gino Lucente, Federica Feliciani, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 292 KB

english, 2009

39

Structure–activity relationships of diphenylpiperazine N-type calcium channel inhibitors

Hassan Pajouhesh, Zhong-Ping Feng, Yanbing Ding, Lingyun Zhang, Hossein Pajouhesh, Jerrie-Lynn Morrison, Francesco Belardetti, Elizabeth Tringham, Eric Simonson, Todd W. Vanderah, Frank Porreca, Geral

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 314 KB

english, 2010

40

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain

Yeon Sun Lee, Steve Fernandes, Vinod Kulkarani, Alexander Mayorov, Peg Davis, Shou-wu Ma, Kathy Brown, Robert J. Gillies, Josephine Lai, Frank Porreca, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 511 KB

english, 2010

41

Biousian glycopeptides penetrate the blood–brain barrier

Richard D. Egleton, Edward J. Bilsky, Gordon Tollin, Muthu Dhanasekaran, John Lowery, Isabel Alves, Peg Davis, Frank Porreca, Henry I. Yamamura, Larisa Yeomans, Charles M. Keyari, Robin Polt

Journal:

Tetrahedron: Asymmetry

Year:

2005

Language:

english

File:

PDF, 742 KB

english, 2005

42

Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides

John M. Ndungu, James P. Cain, Peg Davis, Shou-W. Ma, Todd W. Vanderah, Josephine Lai, Frank Porreca, Victor J. Hruby

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

43

Synthesis and biological activities of ykfa analogues: effects of position 4 substitutions and altered ring size on In vitro opioid activity

John E Burden, Peg Davis, Frank Porreca, Arno F Spatola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 97 KB

english, 2002

44

Synthesis, opioid receptor binding, and functional activity of 5′-substituted 17-cyclopropylmethylpyrido[2′,3′:6,7]morphinans

Subramaniam Ananthan, Hollis S Kezar, III, Surendra K Saini, Naveen K Khare, Peg Davis, Christina M Dersch, Frank Porreca, Richard B Rothman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

45

The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic

Subo Liao, Jun Lin, Mark D. Shenderovich, Yinglin Han, Keiko Hasohata, Peg Davis, Wei Qiu, Frank Porreca, Henry I. Yamamura, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 243 KB

english, 1997

46

Modifications of the 4,4′-residues and sar studies of biphalin, a highly potent opioid receptor active peptide

Guigen Li, W. Haq, Li Xiang, Bih-Show Lou, Robert Hughes, Irene A. De Leon, Peg Davis, Terrence J. Gillespie, Marek Romanowski, Xiaoyun Zhu, Aleksandra Misicka, Andrzej W. Lipkowski, Frank Porreca, Th

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 300 KB

english, 1998

47

Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

Andrzej W. Lipkowski, Aleksandra Misicka, Peg Davis, Dagmar Stropova, Jacqueline Janders, Magdalena Lachwa, Frank Porreca, Henry I. Yamamura, Victor J. Hruby

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 203 KB

english, 1999

48

Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA

John E. Burden, Peg Davis, Frank Porreca, Arno F. Spatola

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 344 KB

english, 1999

49

Novel ligands for the opioid receptors: synthesis and structure–activity relationships among 5′-aryl and 5′-heteroaryl 17-cyclopropylmethyl-4,5α-epoxypyrido[2′,3′:6,7]morphinans

Subramaniam Ananthan, Naveen K Khare, Surendra K Saini, Peg Davis, Christina M Dersch, Frank Porreca, Richard B Rothman

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 343 KB

english, 2003

50

Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats

Todd W. Vanderah, Robert B. Raffa, Jason Lashbrook, Andrew Burritt, Victor Hruby, Frank Porreca

Journal:

European Journal of Pain

Year:

1998

Language:

english

File:

PDF, 1.31 MB

english, 1998